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GENERAL APPLICATIONS
ALFACEL-P is the trade name for Micro Crystalline Cellulose Powder (MCCP) manufactured by the company. ALFACEL-P is made from purified partially depolymerised Alfa Cellulose relatively free from both organic and inorganic contaminants. It is insoluble in water; dilute acids, common organic solvents and oils. Partially soluble with swelling in dilute alkali. It is fine, white, and odour less, edible and metabolically inert powder.
ALFACEL-P conforms the standards of USNF, EP, BP and IP
APPLICATIONS
Alfacel is a product designed for Pharmaceutical solid dosage formulation. Its suitability for tableting operations is shown by the number and variety of functions it can perform.
Direct Compression
• Binder
• Disintegrant
• Flow aid
• Filler
Wet granulation
• Binder.
• Rapid Wicking action
• permits fast addition of granulation fluid
Alfacel can be used in all methods of tableting. It is most effectively used in direct compression. When using Alfacel only a simple three step procedure of weighing, mixing and compressing required. Because of its high chemical purity and low moisture content it improves chemical and color stability of the tablets.
GENERAL ADVANTAGES OF USING ALFACEL.
• Performs on all types of equipments.
• Coherent Slug transfer
• Low friability
• High compressible even with problem formulations
• Low lubricant sensitivity
• Non desiccating
• Uniformity lot to lot
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| APPLICATION |
| FOODS |
| COSMETICS |
| PHARMACEUTICALS |
| ENCAPSULATION WITH ALFACEL |
| CHROMATOGRAPHY |
| ANIMAL HEALTH PRODUCTS CONTAINING ALFACEL |
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| OTHER GRADES OF ALFACEL-P AND TYPICAL PHYSICAL PROPERTIES |
| Type |
Typical Avg Particle size m |
Bulk Density g/cc |
Loss on Drying % |
Specific Characteristics of the grades / Uses |
| 101 |
50 |
0.28 |
7 |
It has a high degree of formulation versatility in a variety of pharmaceutical operations like direct compression tableting and wet granulation |
| 102 |
100 |
0.30 |
7 |
It has a high degree of formulation versatility in a variety of pharmaceutical operations like direct compression tableting and wet granulation |
| 103 |
50 |
0.28 |
2 |
It has low moisture content; so is useful with moisture sensitive materials by eliminating pre- drying of the material and also provide cost savings and manufacturing throughput. It also allows to formulate directly compressible moisture sensitive actives. |
| 105 |
20 |
0.25 |
3 |
It has clearly distinguished smaller Particle size, which is helpful in matching particle size to specific needs, and also increases the absorption and adsorption capacities of the material. |
| 112 |
90 |
0.35 |
0 |
It has low moisture content; so is useful with moisture sensitive materials by eliminating pre- drying of the material and also provide cost savings and manufacturing throughput. It also allows formulating directly compressible moisture sensitive actives. |
| 113 |
50 |
0.30 |
1 |
It has low moisture content; so is useful with moisture sensitive materials by eliminating pre- drying of the material and also provide cost savings and manufacturing throughput. It also allows formulating directly compressible moisture sensitive actives. |
| 200 |
180 |
0.32 |
4 |
It has large particle size developed to control flow deficiencies exhibited by certain formulations where drug properties show inferior flow. It is used for Direct compression wet granulation |
| 301 |
50 |
0.38 |
4 |
Apart from the unique Compressing characteristics it also possess higher densities, which is freely flowable resulting in increased tablet, flow rates, greater tablet weight uniformity and the potential for making smaller tablets. |
| 302 |
90 |
0.39 |
4 |
Apart from the unique Compressing characteristics it also possess higher densities, which is freely flowable resulting in increased tablet, flow rates, greater tablet weight uniformity and the potential for making smaller tablets. |
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| Original grades |
101 ®* and 102 ® * |
| Low moisture grades |
103,112,113 |
| Large Particle size |
200 |
| High density |
301 and 302 |
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